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Use of positron emission tomography (PET) in pharmacokinetic ,Drug absorption and bioavailability ,Effects of renal disease on pharmacokinetics
Noncompartmental vs. compartmental approaches to PK analysis ,Effects of liver disease on pharmacokinetics ,Population pharmacokinetics
DRUG METABOLISM AND TRANSPORT
Pathways of drug metabolism ,Drug Interactions ,Pharmacogenomics ,Molecular and cellular mechanisms of severe adverse drug reactions
Equilibrative and concentrative drug transport
ASSESSMENT OF DRUG EFFECTS
Dose response and concentration response analysis ,Disease progression models and clinical trial simulation ,Physiological and laboratory markers of drug effect
OPTIMIZING AND EVALUATING PATIENT THERAPY
Clinical analysis of adverse drug reactions ,Drug therapy in the elderly ,Drug therapy in pregnant and nursing women ,Developmental and pediatric pharmacology ,Quality assessment of drug therapy
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Topics like Design of clinical drug development programs & the assignment help on these topics is really helpful if you are struggling with the complex problems.
1) Define agonist, antagonist and partial agonist
2) In the paper by Brockhoff et al (2011), the authors tested the activity of two substances on the human taste receptor hTAS2R46.
2.1 – What were these substances? Were they similar to any natural compounds that activate this receptor?
2.2 – What effect these substances exerted on the hTAS2R46 receptor? Were these effects similar for the range of hTAS2R46 activators studied?
2.3 – In your opinion, what was the piece of data that best supported their conclusions about the effects of these two substances on the hTAS2R46 receptor? (do not simply put the figure number, make sure to argument your answer).
A novel compound, Feelgoodasil, has been identified as a new potential anti-depressant compound. Please identify 3 critical experiments (in total) you would perform to
A) Analyze if the drug binds the receptor
B) Analyze where the drug binds in an animal model
C) What response Feelgoodasil elicits in a relevant system (in vitro or otherwise)
- Pharmacology and Physiology, Pathophysiology & Pharmacology Principles, Peripheral Nervous System, Immune System, Inflammation, Arthritis & Gout , Renal Function, Fluid & Electrolyte Balance , Respiratory & GI Systems, Cardiovascular System, Central Nervous System, Cancer and Hematopoietic Diseases, Infectious Diseases, Endocrine System, General nomenclature, Pharmaceutical Preparations, Pharmacokinetics , Routes of administration , Absorption of drugs , Bioavailability , Distribution of drugs
- Blood flow, Volume of distribution, Protein binding, Drug Metabolism , Drug elimination , Kinetics of intravenous infusion , Kinetics of fixed dose regimes , Drug Receptor Interaction and Pharmacodynamics , Chemistry of receptors and ligands , Dose response quantitation , Therapeutic index , The Autonomic Nervous System , Chemical signaling between cells , Second messenger systems
- Cholinergic Agonists , Direct acting agonists , Reversible cholinesterase inhibitors , Irreversible anticholinesterases , Cholinergic Antagonists, Antimuscarinic agents , Neuromuscular blocking drugs , Adrenergic Agonists, Direct acting agonists , Indirect-acting , Adrenergic Antagonists, Alpha blocking agents , Beta blocking agents , Drugs affecting release or reuptake of neurotransmitters , Anxiolytic and Hypnotic Drugs , Benzodiazepines , Barbiturates , CNS Stimulants, Anesthetics, Induction, maintenance and recovery , Inhalation anesthetics
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B M S 554. General Pharmacology
General principles, drug disposition, drugs acting on the nervous, cardiovascular, renal, gastrointestinal, endocrine systems